TL;DR
No. Skip Windex on modern TVs, a dry microfiber cloth or a screen-safe cleaner is the right tool.
Windex is the reflex reach for anything glass, but most modern TV screens aren't actually plain glass. LCD, LED, OLED, and plasma screens carry thin anti-glare or anti-reflective coatings that standard glass cleaner can damage.
The ammonia in traditional Windex is the specific problem, it can break down these coatings over repeated use, leaving cloudy patches or streaks that don't wipe away.
Why Ammonia-Based Cleaners Are the Wrong Choice
Most flat-panel TVs have a coating designed to reduce glare and reflection. Ammonia, a core ingredient in traditional Windex, can react with that coating over time, causing discoloration, cloudiness, or a hazy finish that isn't reversible. Manufacturers like Samsung and LG explicitly warn against ammonia-based or alcohol-based glass cleaners in their care instructions.
How to Clean a TV Screen Correctly
Turn the TV off first, smudges and dust show up more clearly on a dark screen. Wipe gently with a dry microfiber cloth in a single direction rather than scrubbing in circles. For fingerprints, lightly dampen the cloth, not the screen, with distilled water, or use a cleaner specifically labeled safe for LCD or LED screens.
What to Do About Stubborn Smudges
Mix a few drops of dish soap into distilled water for a slightly stronger solution, dampen the cloth lightly, and wipe in one direction. Never spray liquid directly onto the screen, it can run down into the bezel and reach internal components, causing lasting damage.
Mistakes That Cause Real Damage
Paper towels and standard cloths can leave micro-scratches since they're more abrasive than microfiber. Pressing hard to remove a stuck-on smudge can crack the panel underneath the coating. Any alcohol-based or ammonia-based cleaner, including most glass and multi-surface sprays, should stay off the screen entirely unless the manufacturer's manual explicitly says otherwise.
A dry microfiber cloth handles most TV screen cleaning, and a barely damp cloth with distilled water covers the rest. Save the Windex for actual windows, the ammonia in it isn't worth the risk to a screen's coating.